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Valproate pregnancy prevention — GPhC CRA MCQ

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HardCNS TherapeuticsValproate pregnancy preventionGPhC CRA

A 24-year-old woman taking sodium valproate for epilepsy asks for a repeat prescription. She says she may try to conceive within the next year and has not had a recent specialist review. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Supply if clinically necessary and urgently refer for specialist review of valproate risk

Valproate is highly teratogenic and is subject to strict pregnancy prevention and specialist oversight requirements. Abrupt cessation in epilepsy can precipitate seizures, so a pharmacist should not advise stopping without specialist input. The patient needs urgent specialist review and counselling. Folic acid does not remove valproate-associated fetal risk.

Reference: MHRA; BNF