Warfarin and metronidazole — GPhC CRA MCQ
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Correct answer: D — INR and symptoms of bleeding during and after the antibiotic course
Metronidazole can enhance the anticoagulant effect of warfarin and increase INR. The patient should have anticoagulation clinic or prescriber advice about INR monitoring and bleeding symptoms. The effect can be clinically significant even with short courses. The other monitoring options do not assess warfarin safety.
Reference: BNF