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Drug-induced hyponatraemia — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyDrug-induced hyponatraemiaGPhC CRA

An 82-year-old woman started sertraline three weeks ago and now has confusion, falls and reduced appetite. She also takes bendroflumethiazide. What monitoring is required?

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Correct answer: A — Check serum sodium and assess for SSRI-related hyponatraemia

SSRIs can cause hyponatraemia, especially in older people. Thiazide diuretics can also lower sodium, increasing risk. Confusion and falls are compatible with clinically significant hyponatraemia. Serum sodium should be checked and the prescriber contacted urgently.

Reference: BNF; NICE CKS