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Antiviral renal dosing — GPhC CRA MCQ

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HardInfectionsAntiviral renal dosingGPhC CRA

An 82-year-old man with shingles is prescribed aciclovir 800mg five times daily. His eGFR is 24 mL/min/1.73m2 and he has poor oral intake. What monitoring is required?

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Correct answer: CRenal function should be used to assess aciclovir dose suitability

Aciclovir is renally eliminated and dose adjustment may be needed in renal impairment. Poor oral intake increases risk of dehydration and renal adverse effects. The pharmacist should contact the prescriber to confirm an appropriate regimen. INR, peak flow and cholesterol do not guide aciclovir dosing.

Reference: BNF