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Antidepressant discontinuation — GPhC CRA MCQ

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EasyCNS TherapeuticsAntidepressant discontinuationGPhC CRA

A 46-year-old woman has taken venlafaxine modified-release for eight months and feels well. She asks whether she can stop it tomorrow because she has a holiday planned. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Discuss gradual dose reduction with the prescriber

Venlafaxine is associated with discontinuation symptoms if stopped abruptly. A planned gradual reduction reduces the risk of dizziness, flu-like symptoms, insomnia and anxiety. The prescriber should advise a tapering schedule based on dose and history. St John's wort can interact with serotonergic medicines.

Reference: BNF; NICE CKS