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Domperidone cardiac risk — GPhC CRA MCQ

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ModerateGastro-intestinal TherapeuticsDomperidone cardiac riskGPhC CRA

A 75-year-old woman asks to buy domperidone for nausea. She takes amiodarone and has a history of prolonged QT interval. She has been vomiting for 24 hours. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Do not supply and refer for medical assessment

Domperidone is associated with QT prolongation and serious cardiac arrhythmia risk. Existing QT prolongation and amiodarone use make supply inappropriate. Ongoing vomiting in an older person may also require assessment for dehydration and underlying cause. Loperamide is not an antiemetic.

Reference: BNF; MHRA