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Carbimazole agranulocytosis — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsCarbimazole agranulocytosisGPhC CRA

A 37-year-old woman taking carbimazole 20mg daily for Graves' disease asks about a new sore throat and fever that started today. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Stop carbimazole and seek urgent full blood count assessment

Carbimazole can rarely cause agranulocytosis, which may present with sore throat, fever or mouth ulcers. The patient should stop treatment and seek urgent assessment including full blood count. Continuing treatment without evaluation could be dangerous. Dose increases would worsen risk.

Reference: BNF; NICE CKS