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Clozapine infection warning — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyClozapine infection warningGPhC CRA

A 43-year-old man taking clozapine reports sore throat, fever and mouth ulcers. His next clozapine blood test is due in five days. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Arrange urgent full blood count advice through the clozapine monitoring pathway

Clozapine can cause neutropenia and agranulocytosis. Fever, sore throat or mouth ulcers require urgent blood count assessment according to the clozapine monitoring service. Delaying until the routine test could miss serious harm. Psychiatric medicines should not be stopped broadly without specialist advice.

Reference: BNF; clozapine monitoring service