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Metoclopramide in renal impairment — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentMetoclopramide in renal impairmentGPhC CRA

A 69-year-old man with eGFR 22 mL/min/1.73m2 is prescribed metoclopramide 10mg three times daily for nausea. He is frail and has a history of extrapyramidal symptoms. What monitoring is required?

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Correct answer: B — Dose suitability, duration and extrapyramidal adverse effects

Metoclopramide requires caution in renal impairment and in patients at risk of extrapyramidal adverse effects. Treatment duration should be limited according to safety guidance. Frailty increases the need to minimise adverse CNS effects and falls. The other monitoring options do not address metoclopramide safety.

Reference: BNF