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Phenytoin and enteral feed — GPhC CRA MCQ

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ModerateDrug InteractionsPhenytoin and enteral feedGPhC CRA

A care home resident receives phenytoin liquid via a feeding tube and continuous enteral feed. Seizures have increased after the feeding regimen changed. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Enteral feed may reduce phenytoin absorption

Enteral feeds can reduce phenytoin absorption and lead to subtherapeutic levels. Administration timing, tube flushing and level monitoring may need review. Increased seizures after a feeding change is clinically consistent with reduced exposure. The pharmacist should liaise with the prescriber and nutrition team.

Reference: BNF; SPS