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Azole and simvastatin — GPhC CRA MCQ

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ModerateDrug InteractionsAzole and simvastatinGPhC CRA

A 64-year-old woman taking simvastatin 40mg nightly asks for oral fluconazole for recurrent thrush. She reports previous muscle pains on statins. What is the most important interaction to flag?

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Correct answer: B — Fluconazole may increase statin-related muscle toxicity risk

Azole antifungals can increase exposure to some statins and increase risk of myopathy. The patient's previous statin muscle symptoms increase concern. A pharmacist should consider alternative treatment or prescriber advice depending on severity and recurrence. Dissolution failure is not the relevant mechanism.

Reference: BNF