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Methotrexate monitoring — GPhC CRA MCQ

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ModerateMusculoskeletal TherapeuticsMethotrexate monitoringGPhC CRA

A 58-year-old woman has started methotrexate for rheumatoid arthritis. She asks what blood tests are needed while the dose is being adjusted. What monitoring is required?

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Correct answer: C — Full blood count, liver function and renal function

Methotrexate can cause bone marrow suppression, hepatotoxicity and renal-related toxicity. Full blood count, liver function and renal function are core monitoring tests. Frequency depends on initiation, dose changes and local shared-care arrangements. Patients should report sore throat, mouth ulcers, bruising or breathlessness.

Reference: NICE CKS; SPS; BNF