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Montelukast neuropsychiatric effects — GPhC CRA MCQ

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ModerateRespiratory TherapeuticsMontelukast neuropsychiatric effectsGPhC CRA

A parent asks about montelukast 5mg chewable tablets prescribed for a 9-year-old child with asthma and allergic rhinitis. The child has recently become anxious and has vivid dreams after starting treatment. What is the most appropriate alternative?

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Correct answer: A — Seek prescriber review because montelukast can be associated with neuropsychiatric reactions

Montelukast has recognised neuropsychiatric adverse effects, including sleep disturbance, mood changes and anxiety. New behavioural symptoms after initiation should prompt review of benefit and risk. The parent should not alter the dose without prescriber advice. Asthma preventer treatment should not be stopped abruptly without a plan.

Reference: MHRA; BNF