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Lithium toxicity and NSAIDs — GPhC CRA MCQ

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HardCNS TherapeuticsLithium toxicity and NSAIDsGPhC CRA

A 48-year-old woman taking lithium carbonate modified-release tablets asks to buy ibuprofen for a sprained ankle. She has had vomiting and reduced fluid intake for two days. What is the most important interaction to flag?

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Correct answer: A — Ibuprofen and dehydration may increase lithium toxicity risk

NSAIDs can increase lithium levels and toxicity risk. Dehydration and vomiting further increase risk by affecting renal handling of lithium. Symptoms such as tremor, ataxia, diarrhoea or confusion require urgent assessment. The pharmacist should recommend safer analgesia and refer appropriately.

Reference: BNF