skip to main content

Pancreatic enzyme replacement — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardGastro-intestinal TherapeuticsPancreatic enzyme replacementGPhC CRA

A patient prescribed Creon 25000 cannot swallow capsules. Which method preserves the enteric coating and matches the authorised instructions?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Open onto acidic soft food, swallow immediately without chewing and do not store

Creon capsules may be opened when swallowing is difficult, but the enteric-coated granules must remain intact. They can be mixed with a small amount of acidic soft food or fluid and swallowed immediately without chewing; the mixture must not be stored. Crushing, chewing, heat or a fluid above pH 5.5 can disrupt the coating, release enzymes in the mouth, reduce efficacy and irritate mucosa.

Reference: Creon 25000 Capsules SmPC: https://www.medicines.org.uk/emc/product/1168/smpc