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Opioid and benzodiazepine sedation — GPhC CRA MCQ

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ModerateCNS TherapeuticsOpioid and benzodiazepine sedationGPhC CRA

A 66-year-old man takes diazepam 5mg at night and presents with a new prescription for oxycodone immediate-release capsules after surgery. He lives alone and has COPD. What is the most important interaction to flag?

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Correct answer: D — Oxycodone with diazepam increases sedation and respiratory depression risk

Opioids and benzodiazepines have additive CNS depressant effects. The risk is greater in older people and those with respiratory disease such as COPD. The pharmacist should counsel carefully and contact the prescriber if the combination seems unsafe. Hypertension and chelation are not the main concerns.

Reference: BNF