skip to main content

Penicillin allergy and antibiotic choice — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyInfectionsPenicillin allergy and antibiotic choiceGPhC CRA

A woman prescribed amoxicillin for sinusitis tells you she had immediate facial swelling and wheeze after penicillin as a child. The prescription is due to be supplied today. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Contact the prescriber for a non-penicillin alternative

Immediate swelling and wheeze after penicillin suggest possible IgE-mediated allergy. Amoxicillin should not be supplied without prescriber review. Flucloxacillin is also a penicillin, so it is not a safe substitution. Taking with food does not prevent serious allergy.

Reference: NICE CKS; BNF