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SSRI early adverse effects — GPhC CRA MCQ

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EasyCNS TherapeuticsSSRI early adverse effectsGPhC CRA

A 29-year-old woman starts sertraline 50mg daily for depression. She asks why the GP booked a review in two weeks and whether she should expect immediate benefit. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Explain that benefit may take a few weeks and early worsening or suicidal thoughts need urgent help

SSRIs often take several weeks to produce clear antidepressant benefit. Early adverse effects such as nausea may occur, and younger adults should be counselled to seek help urgently if suicidal thoughts or agitation worsen. Extra doses increase adverse effects without improving short-term response. St John's wort can interact with antidepressants and should not be added casually.

Reference: BNF; NICE CKS