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Rivaroxaban and NSAID — GPhC CRA MCQ

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EasyDrug InteractionsRivaroxaban and NSAIDGPhC CRA

A 71-year-old man taking rivaroxaban for atrial fibrillation asks to buy diclofenac tablets for shoulder pain. He has had a previous gastrointestinal bleed. What is the most important interaction to flag?

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Correct answer: A — Diclofenac may increase bleeding risk with rivaroxaban

NSAIDs increase gastrointestinal bleeding risk and can add to anticoagulant-related bleeding risk. Previous gastrointestinal bleeding makes this more concerning. The pharmacist should avoid OTC oral diclofenac and discuss safer options or refer. The interaction is pharmacodynamic rather than a chelation effect.

Reference: BNF