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Oral retinoid and tetracycline — GPhC CRA MCQ

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ModerateDrug InteractionsOral retinoid and tetracyclineGPhC CRA

A 20-year-old woman taking isotretinoin for acne is prescribed doxycycline by an urgent care clinician for suspected chest infection. She asks whether the combination is safe. What is the most important interaction to flag?

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Correct answer: E — Doxycycline with isotretinoin may increase intracranial hypertension risk

Tetracyclines and retinoids have both been associated with intracranial hypertension. The combination should generally be avoided, and the prescriber should be contacted. The patient should also be counselled to seek help for severe headache or visual disturbance. The combination does not reduce isotretinoin teratogenicity.

Reference: BNF