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SGLT2 inhibitor sick day advice — GPhC CRA MCQ

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EasyEndocrine TherapeuticsSGLT2 inhibitor sick day adviceGPhC CRA

A 58-year-old woman takes empagliflozin for type 2 diabetes. She has vomiting and poor oral intake due to gastroenteritis and asks whether to continue her medicines. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Temporarily withhold empagliflozin and seek advice if ketone symptoms occur

SGLT2 inhibitors can increase the risk of diabetic ketoacidosis, including during acute illness, dehydration or reduced intake. Temporary withholding during significant illness is part of sick day advice. The patient should seek urgent help for symptoms such as abdominal pain, vomiting, deep breathing or ketone positivity. Insulin should not be stopped permanently without clinical advice.

Reference: BNF; NICE CKS