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SSRI and NSAID bleeding risk — GPhC CRA MCQ

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ModerateCNS TherapeuticsSSRI and NSAID bleeding riskGPhC CRA

A 63-year-old man takes fluoxetine 20mg daily and asks to buy naproxen for back pain. He has a history of peptic ulcer disease and takes no gastroprotection. What is the most important interaction to flag?

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Correct answer: D — Fluoxetine with naproxen increases gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs further increase gastrointestinal bleeding risk. A previous peptic ulcer increases concern. The pharmacist should consider safer analgesia and refer where NSAID use is being considered. The other options do not identify the clinically relevant interaction.

Reference: BNF