Opisthorchiasis — DTM&H MCQ

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HardHelminthic InfectionsOpisthorchiasisDTM&H

A Cambodian man with long-standing Clonorchis sinensis infection has recurrent pyogenic cholangitis. Which complication is most specifically associated with chronic infection and should influence long-term assessment?

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Correct answer: B — Cholangiocarcinoma

The best answer is “Cholangiocarcinoma”. Chronic clonorchiasis and opisthorchiasis cause biliary inflammation and are established risk factors for bile-duct cancer. Hepatocellular, pancreatic, colorectal and renal-cell carcinomas are not the characteristic malignancy linked to these adult liver flukes. The association adds importance to preventing reinfection and evaluating persistent biliary symptoms even after anthelmintic treatment.

Reference: WHO fact sheet: foodborne trematode infections: https://www.who.int/news-room/fact-sheets/detail/foodborne-trematode-infections