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ACT pharmacology — DTM&H MCQ

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HardMalariaACT pharmacologyDTM&H

A patient with uncomplicated falciparum malaria starts artemether-lumefantrine but has nausea and can manage only small oral volumes. Which instruction most directly reduces the risk of subtherapeutic lumefantrine exposure?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Take each dose with milk or another tolerated fat-containing intake

The best answer is “Take each dose with milk or another tolerated fat-containing intake”. Lumefantrine is lipophilic and absorption rises substantially with dietary fat. Milk or another tolerated fatty intake should accompany each dose; if food cannot be taken, clinical and parasitological follow-up is particularly important because exposure and cure may be reduced.

Reference: Riamet 20 mg/120 mg tablets, UK Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/1628/smpc