skip to main content

IPTp mechanism of action — DTM&H MCQ

Instant feedback + full explanation. One question, done properly.

HardMalariaIPTp mechanism of actionDTM&H

A pregnant woman in Papua New Guinea receives intermittent preventive treatment with sulfadoxine-pyrimethamine at 26 weeks' gestation. What is the primary mechanism by which IPTp reduces adverse pregnancy outcomes?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — It clears parasites sequestered in the placenta

IPTp with SP works primarily by clearing parasites from the placental intervillous spaces, where P. falciparum preferentially sequesters via VAR2CSA-mediated binding to chondroitin sulphate A. Placental malaria causes low birth weight, preterm delivery, and maternal anaemia. SP does not prevent new infections but periodic clearance of placental parasites reduces cumulative damage. WHO recommends SP at each scheduled antenatal visit from the second trimester, at least one month apart.

Reference: WHO IPTp Guidelines; Manson's Tropical Diseases