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Fascioliasis — DTM&H MCQ

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HardHelminthic InfectionsFascioliasisDTM&H

A patient with stool-confirmed Fasciola hepatica infection receives triclabendazole 10 mg/kg once with food. Symptoms and viable eggs persist on appropriately timed reassessment. What is the WHO-supported next drug regimen?

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Correct answer: E — Triclabendazole 10 mg/kg twice daily for one day

The best answer is “Triclabendazole 10 mg/kg twice daily for one day”. WHO recommends triclabendazole 10 mg/kg once for fascioliasis and permits escalation to 20 mg/kg in two divided doses, separated by 12–24 hours, after treatment failure. Praziquantel is used for clonorchiasis, opisthorchiasis and as an alternative for paragonimiasis, but not as the reliable Fasciola rescue regimen. The other anthelmintics do not provide the recommended escalation.

Reference: WHO fact sheet: foodborne trematode infections: https://www.who.int/news-room/fact-sheets/detail/foodborne-trematode-infections