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Tricyclic antidepressant overdose treatment — ABEM Board MCQ

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HardToxicologyTricyclic antidepressant overdose treatmentABEM Board

A 44-year-old man arrives after ingesting amitriptyline. Triage acuity is ESI 1; BP 78/42 mm Hg, HR 136/min. He is obtunded, and ECG shows QRS 170 ms. He has received airway support and IV access is established. Which of the following is the most important immediate intervention?

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Correct answer: EGive IV sodium bicarbonate boluses

Wide-complex dysrhythmia and hypotension from TCA sodium-channel blockade are treated with IV sodium bicarbonate.

Reference: ACMT tricyclic antidepressant poisoning guidance