skip to main content

Eosinophilic granulomatosis with polyangiitis — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

HardVasculitisEosinophilic granulomatosis with polyangiitisSCE Rheumatology

A patient with eosinophilic granulomatosis with polyangiitis has mononeuritis multiplex and cardiac MRI-confirmed myocarditis. Which induction strategy best fits this organ-threatening phenotype?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — High-dose glucocorticoid plus cyclophosphamide or rituximab

Myocarditis and vasculitic neuropathy make this organ-threatening EGPA. Induction requires high-dose glucocorticoid plus cyclophosphamide or rituximab. Anti-IL-5 treatment is principally used for relapsing or refractory non-organ-threatening EGPA, and maintenance agents alone are insufficient for this presentation.

Reference: 2025 BSR management recommendations for ANCA-associated vasculitis (Published June 2025): https://academic.oup.com/rheumatology/article/64/8/4470/8160140; EULAR recommendations for ANCA-associated vasculitis — 2022 update (Published 2024): https://ard.bmj.com/content/83/1/30