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Antiphospholipid syndrome — SCE Rheumatology MCQ

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HardConnective Tissue DiseasesAntiphospholipid syndromeSCE Rheumatology

A patient has an unprovoked proximal DVT and three first-trimester miscarriages. Lupus anticoagulant and anticardiolipin IgG remain positive 14 weeks after initial testing. What is the diagnosis?

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Correct answer: B — Thrombotic and obstetric antiphospholipid syndrome with persistent antibodies

A qualifying venous thrombosis, recurrent pregnancy morbidity and persistent antiphospholipid antibodies measured at least 12 weeks apart support antiphospholipid syndrome. A weak ANA or mild thrombocytopenia does not establish another diagnosis.

Reference: BSH guideline on investigation and management of antiphospholipid syndrome (Published July 2024; reviewed August 2025): https://cms.b-s-h.org.uk/guidelines/guidelines/guidelines-on-the-investigation-and-management-of-antiphospholipid-syndrome; EULAR recommendations for management of antiphospholipid syndrome (Published 2019): https://ard.bmj.com/content/78/10/1296