skip to main content

Oligoarticular juvenile idiopathic arthritis — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

HardPaediatric RheumatologyOligoarticular juvenile idiopathic arthritisSCE Rheumatology

A woman taking upadacitinib for inflammatory arthritis plans conception. Disease can be bridged with pregnancy-compatible treatment. What is the minimum BSR pre-conception withdrawal interval for a JAK inhibitor?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Stop at least 2 weeks before attempting conception

Explanation lettering: E = shown as B · D = shown as C · C = shown as D · B = shown as E

C is correct. The BSR pregnancy table recommends stopping JAK inhibitors at least two weeks before conception; they are not considered compatible during pregnancy or breastfeeding because human exposure data are limited and animal data raise concern. A longer interval may appear in individual product information and should still be checked, but the question asks specifically for the BSR minimum. Disease control should be transferred deliberately to a compatible therapy rather than allowing an avoidable pre-conception flare.

Reference: BSR guideline on prescribing immunomodulatory anti-rheumatic drugs in pregnancy and breastfeeding: https://academic.oup.com/rheumatology/article/62/4/1370/6783014