skip to main content

Eosinophilic granulomatosis with polyangiitis — SCE Rheumatology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateVasculitisEosinophilic granulomatosis with polyangiitisSCE Rheumatology

A 31-year-old woman has adult-onset asthma, nasal polyps, pulmonary infiltrates, eosinophils 4.8 × 10^9/L and mononeuritis multiplex. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Eosinophilic granulomatosis with polyangiitis

Eosinophilic granulomatosis with polyangiitis is the single best answer because asthma with eosinophilia, sinus disease and vasculitic neuropathy suggests EGPA. The stem is testing diagnostic synthesis, not isolated recall, so the relevant clinical pattern and risk context determine the answer. Migraine is less suitable because it fits a different clinical pattern or a different treatment threshold; Sarcoidosis, Aspirin monotherapy and Etanercept do not address the key discriminator in this vignette. Clinical pearl: in SCE-style rheumatology questions, autoantibodies, imaging and synovial fluid findings should be interpreted with the whole phenotype.

Reference: BSR/EULAR vasculitis recommendations; NICE technology appraisals; BNF