PR3-ANCA vasculitis — SCE Rheumatology MCQ
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Correct answer: C — Granulomatosis with polyangiitis
Granulomatosis with polyangiitis is the single best answer because PR3-ANCA with ENT, lung and renal disease supports GPA. The stem is testing diagnostic synthesis, not isolated recall, so the relevant clinical pattern and risk context determine the answer. Rheumatoid arthritis is less suitable because it fits a different clinical pattern or a different treatment threshold; Systemic lupus erythematosus, Psoriatic arthritis and Gout do not address the key discriminator in this vignette. Clinical pearl: in SCE-style rheumatology questions, autoantibodies, imaging and synovial fluid findings should be interpreted with the whole phenotype.
Reference: BSR hot swollen joint guidance; EULAR imaging/autoantibody recommendations