Systemic lupus erythematosus — SCE Rheumatology MCQ
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Correct answer: A — Systemic lupus erythematosus
Systemic lupus erythematosus is the single best answer because mucocutaneous disease with anti-dsDNA, hypocomplementaemia and renal urinary abnormalities indicates active SLE nephritis. The stem is testing diagnostic synthesis, not isolated recall, so the relevant clinical pattern and risk context determine the answer. Mixed connective tissue disease is less suitable because it fits a different clinical pattern or a different treatment threshold; Primary Sjögren's disease, Repeat ANA titre alone and Adalimumab do not address the key discriminator in this vignette. Clinical pearl: in SCE-style rheumatology questions, autoantibodies, imaging and synovial fluid findings should be interpreted with the whole phenotype.
Reference: BSR/EULAR connective tissue disease recommendations; BNF