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Primary Sjögren's disease — SCE Rheumatology MCQ

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EasyConnective Tissue DiseasesPrimary Sjögren's diseaseSCE Rheumatology

A 28-year-old woman has gritty eyes, dental caries, dry mouth, bilateral parotid enlargement, abnormal Schirmer test and anti-Ro positivity. What is the most appropriate management?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: AUse tear and saliva replacement or stimulation with preventive dental care

Use tear and saliva replacement or stimulation with preventive dental care is the single best answer because objective sicca with anti-Ro antibodies supports primary Sjögren's disease. The stem is testing management choice, not isolated recall, so the relevant clinical pattern and risk context determine the answer. Mixed connective tissue disease is less suitable because it fits a different clinical pattern or a different treatment threshold; Primary Sjögren's disease, Repeat ANA titre alone and Adalimumab do not address the key discriminator in this vignette. Clinical pearl: in SCE-style rheumatology questions, autoantibodies, imaging and synovial fluid findings should be interpreted with the whole phenotype.

Reference: BSR/EULAR connective tissue disease recommendations; BNF