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Antiphospholipid syndrome — SCE Rheumatology MCQ

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HardConnective tissue diseasesAntiphospholipid syndromeSCE Rheumatology

A 36-year-old woman with triple-positive APS asks about future risks after an ischaemic stroke. Examination shows blood pressure is controlled. Investigations show she is taking warfarin with variable INR readings. What is the most important complication to screen for?

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Correct answer: B — Recurrent arterial and venous thrombosis

APS is defined by a tendency to recurrent thrombosis and pregnancy morbidity, with triple positivity carrying higher risk. Renal crisis and lymphoma are complications of other connective tissue diseases rather than APS itself. Stable anticoagulation and avoidance of avoidable risk factors are central to preventing recurrence.

Reference: EULAR recommendations; BSR guideline; BNF