A patient with rheumatoid arthritis has primary failure of a TNF inhibitor despite adherence. He has recurrent diverticulitis and previously

Question

A patient with rheumatoid arthritis has primary failure of a TNF inhibitor despite adherence. He has recurrent diverticulitis and previously developed demyelination. Which treatment-selection principle is most appropriate?

Accepted Answer

Choose a different mechanism after comorbidity-focused specialist review

Answer

Select an IL-6 inhibitor solely because diverticulitis is present

Answer

Start a JAK inhibitor without cardiovascular or thrombotic assessment

Answer

Stop disease-modifying treatment permanently

Answer

Use another TNF inhibitor without considering demyelination

RA with inadequate TNF response — SCE Rheumatology MCQ

A patient with rheumatoid arthritis has primary failure of a TNF inhibitor despite adherence. He has recurrent diverticulitis and previously developed demyelination. Which treatment-selection principle is most appropriate?