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APS pregnancy morbidity — SCE Rheumatology MCQ

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ModeratePregnancy in rheumatic disease and rare conditionsAPS pregnancy morbiditySCE Rheumatology

A 34-year-old woman with obstetric APS is newly pregnant after three miscarriages. Examination shows no previous thrombosis is recorded. Investigations show lupus anticoagulant is persistently positive. What is the most appropriate management?

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Correct answer: E — Low-dose aspirin plus prophylactic heparin

Low-dose aspirin plus prophylactic heparin is the most appropriate pregnancy-specific management strategy. The alternatives include teratogenic therapy, inadequate thromboprophylaxis or unsafe delay. Rheumatic disease pregnancy planning should occur before conception whenever possible.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions