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Psoriatic arthritis with severe skin disease — SCE Rheumatology MCQ

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HardSpondyloarthropathiesPsoriatic arthritis with severe skin diseaseSCE Rheumatology

A patient with psoriatic arthritis has active peripheral joints, severe psoriasis and known Crohn disease after methotrexate failure. Which biologic mechanism should generally be avoided because it may exacerbate inflammatory bowel disease?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Interleukin-17 inhibition

IL-17 inhibitors are effective for psoriasis and psoriatic arthritis but are generally avoided in active inflammatory bowel disease because new or worsened IBD can occur. Therapy should be selected jointly to control both joint and bowel disease.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/musculoskeletal-conditions