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Cyclophosphamide safety — SCE Rheumatology MCQ

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ModerateRheumatological pharmacologyCyclophosphamide safetySCE Rheumatology

A 45-year-old woman needs cyclophosphamide for severe vasculitis. Examination shows she is concerned about future fertility. Investigations show renal function is stable and infection screen is complete. What is the most appropriate management?

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Correct answer: B — Discuss fertility preservation and gonadoprotection before treatment

Discuss fertility preservation and gonadoprotection before treatment is the safest management step for this treatment-related scenario. The alternatives either continue a potentially harmful drug, omit essential monitoring, or address the wrong risk. Shared-care DMARD prescribing depends on clear monitoring thresholds and rapid communication with rheumatology.

Reference: BNF; SPS DMARD monitoring guidance; BSR DMARD prescribing guideline