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Cyclospora cayetanensis — DTM&H MCQ

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HardProtozoal infectionsCyclospora cayetanensisDTM&H

An immunocompetent adult has PCR-confirmed Cyclospora infection with three weeks of relapsing diarrhoea after imported soft fruit. Which regimen is first-line when treatment is indicated?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Co-trimoxazole for a complete therapeutic course

The best answer is “Co-trimoxazole for a complete therapeutic course”. Co-trimoxazole is the established first-line treatment for clinically significant cyclosporiasis. Nitazoxanide is used for some other coccidia, metronidazole does not eradicate Cyclospora, and fluoroquinolone or macrolide alternatives are less reliable and require specialist consideration when sulfonamides cannot be used.

Reference: UKHSA: Cyclospora clinical and travel guidance: https://www.gov.uk/guidance/cyclospora-clinical-and-travel-guidance