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Syphilis chancre — DFSRH MCQ

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ModerateSTIsSyphilis chancreDFSRH

A 34-year-old man has a painless penile ulcer and non-tender inguinal lymphadenopathy. He has had new partners and no previous syphilis treatment. What is the most appropriate investigation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Syphilis serology with specialist sexual health assessment

A painless genital ulcer raises concern for primary syphilis and needs serology plus specialist assessment. HSV can still be considered, but it is not the sole test. Partner notification and HIV testing are important.

Reference: BASHH Guidelines; NICE CKS; UKHSA STI guidance; BNF