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Modafinil interaction — DFSRH MCQ

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ModeratePharmacologyModafinil interactionDFSRH

A 30-year-old woman takes modafinil for narcolepsy and asks for the combined pill. She wants to avoid pregnancy because modafinil may be teratogenic. What is the most appropriate contraceptive method?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Copper IUD or another method unaffected by enzyme induction

Modafinil can reduce effectiveness of steroidal contraception through enzyme induction, and avoiding pregnancy is especially important. IUDs or DMPA are preferred reliable options. This question combines interaction and teratogenic-risk counselling.

Reference: BNF; FSRH Drug Interactions with Hormonal Contraception Guidance; UKMEC 2025