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Rifampicin interaction — DFSRH MCQ

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ModerateCombined hormonal contraceptionRifampicin interactionDFSRH

A 33-year-old woman taking rifampicin for tuberculosis asks to start a combined pill. She wants a reliable reversible method during treatment. What is the most appropriate contraceptive method?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Depot medroxyprogesterone acetate injection

Rifampicin is a potent enzyme inducer and reduces effectiveness of CHC and most progestogen-only pills. DMPA is not meaningfully affected and is a suitable reversible option. A copper IUD would also be reliable if acceptable and appropriate.

Reference: FSRH Combined Hormonal Contraception Guideline; UKMEC 2025; BNF