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Lamotrigine rash — GPhC CRA MCQ

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EasyAdverse Drug Reactions and Drug SafetyLamotrigine rashGPhC CRA

A patient who started lamotrigine two weeks ago reports a widespread rash and fever. She asks whether to buy an antihistamine and continue treatment. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Refer urgently because serious skin reaction is possible

Lamotrigine can rarely cause serious skin reactions, particularly early in treatment or after rapid dose escalation. Rash with fever is a red flag requiring urgent clinical assessment. The patient should not simply self-treat and continue without advice.

Reference: BNF