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Macrolide and colchicine — GPhC CRA MCQ

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EasyDrug InteractionsMacrolide and colchicineGPhC CRA

A patient taking colchicine for gout prophylaxis is prescribed clarithromycin for a chest infection. He has mild renal impairment. What is the most important interaction to flag?

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Correct answer: D — Clarithromycin can increase colchicine toxicity risk

Clarithromycin can inhibit colchicine metabolism and transport, increasing risk of serious colchicine toxicity. Renal impairment increases the risk further. The pharmacist should contact the prescriber for an alternative plan.

Reference: BNF