skip to main content

Neuropathic pain first-line — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCNS TherapeuticsNeuropathic pain first-lineGPhC CRA

A 62-year-old with painful diabetic neuropathy cannot tolerate amitriptyline due to dry mouth and sedation. The GP asks the pharmacist for another suitable medicine to consider. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Duloxetine

Duloxetine is one option used for painful diabetic neuropathy and may be considered when amitriptyline is unsuitable. Long-term opioids, benzodiazepines, triptans, and antihistamines do not address the neuropathic pain mechanism appropriately. Treatment choice should consider comorbidities, contraindications, and patient preference.

Reference: NICE CKS; BNF