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Modified-release formulation — GPhC CRA MCQ

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ModerateDispensing and SupplyModified-release formulationGPhC CRA

A prescription states diltiazem 200mg modified-release once daily, but the pharmacy has a different diltiazem modified-release brand in stock. The patient has stable angina. What is the most appropriate alternative?

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Correct answer: A — Check brand or formulation equivalence before substituting

Modified-release diltiazem preparations can have different release characteristics and dosing schedules. Substitution should be made carefully, ideally maintaining brand continuity or checking equivalence. Crushing modified-release products can cause dose dumping and harm.

Reference: BNF; MEP