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Clopidogrel and PPI — GPhC CRA MCQ

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HardCardiovascular TherapeuticsClopidogrel and PPIGPhC CRA

A patient taking clopidogrel after a transient ischaemic attack buys omeprazole for frequent reflux. No PPI has been prescribed previously. What is the most important interaction to flag?

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Correct answer: D — Omeprazole may reduce clopidogrel activation

Omeprazole can inhibit CYP2C19 and may reduce activation of clopidogrel. The pharmacist should consider an alternative acid-suppressing strategy and contact the prescriber if ongoing treatment is needed. The other interactions listed are not the relevant concern.

Reference: BNF