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Nitrofurantoin renal impairment — GPhC CRA MCQ

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ModerateInfection ManagementNitrofurantoin renal impairmentGPhC CRA

A prescription for nitrofurantoin 100mg modified-release twice daily is presented for a frail patient with a documented eGFR of 28mL/min/1.73m2. It is for a lower urinary tract infection. What is the most appropriate alternative?

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Correct answer: E — Query the prescription because renal function is below the usual suitability threshold

Nitrofurantoin depends on renal excretion into the urinary tract and is generally unsuitable in significant renal impairment. An eGFR of 28mL/min/1.73m2 should prompt the pharmacist to query the prescription. The pharmacist should not independently change to another antibiotic.

Reference: BNF; NICE CKS