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DOAC and verapamil — GPhC CRA MCQ

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ModerateDrug InteractionsDOAC and verapamilGPhC CRA

A patient taking dabigatran is prescribed verapamil modified-release for rate control. The patient is 80 years old with reduced renal function. What is the most important interaction to flag?

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Correct answer: C — Verapamil can increase dabigatran exposure and bleeding risk

Verapamil can increase dabigatran concentrations through P-glycoprotein inhibition, and renal impairment increases bleeding risk. The prescription should be checked for dose suitability and timing guidance. The prescriber should be contacted if the plan is unclear.

Reference: BNF